The project is to produce a definite philosophical treatment of Enlightenment vitalism dealing with its philosophy of science, account of mind and body, and relation to competing theories of machines and organisms. Vitalism, the medico-philosophical focus on the uniqueness of biological life, has a complex relation with the development and change of biology and medicine as sciences, and Enlightenment vitalism is its most diverse philosophical form – not least in its ‘speculative’ materialist presentation, in Diderot’s ‘D’Alembert’s Dream’ with its metaphysics of living matter.